Proteomic analysis reveals dexamethasone rescues matrix breakdown but not anabolic dysregulation in a cartilage injury model

Proteomic analysis reveals dexamethasone rescues matrix breakdown but not anabolic dysregulation in a cartilage injury model

Summary: Objectives: In this exploratory study, we used discovery proteomics to follow the release of proteins from bovine knee articular cartilage in response to mechanical injury and cytokine treatment. We also studied the effect of the glucocorticoid dexamethasone (Dex) on these responses. Desig...

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Bibliographic Details
Main Authors: Rebecca Mae Black, Yang Wang, André Struglics, Pilar Lorenzo, Viveka Tillgren, Martin Rydén, Alan J. Grodzinsky, Patrik Önnerfjord
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Osteoarthritis and Cartilage Open
Subjects:
Post-traumatic osteoarthritis
Mass spectrometry
Cartilage matrix
Cytokines
Proteomics
Dexamethasone
Online Access:http://www.sciencedirect.com/science/article/pii/S2665913120300935

Internet

http://www.sciencedirect.com/science/article/pii/S2665913120300935

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