Targeting Mitochondrial Complex I Deficiency in MPP+/MPTP-induced Parkinson’s Disease Cell Culture and Mouse Models by Transducing Yeast NDI1 Gene

Targeting Mitochondrial Complex I Deficiency in MPP+/MPTP-induced Parkinson’s Disease Cell Culture and Mouse Models by Transducing Yeast NDI1 Gene

Abstract Background MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine), original found in synthetic heroin, causes Parkinson’s disease (PD) in human through its metabolite MPP+ by inhibiting complex I of mitochondrial respiratory chain in dopaminergic neurons. This study explored whether yeast inte...

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Bibliographic Details
Main Authors: Hongzhi Li, Jing Zhang, Yuqi Shen, Yifan Ye, Qingyou Jiang, Lan Chen, Bohao Sun, Zhuo Chen, Luxi Shen, Hezhi Fang, Jifeng Yang, Haihua Gu
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Biological Procedures Online
Subjects:
Parkinson’s disease
MPTP
Respiratory chain complex
Yeast NDI1 gene
Viral vector
Therapy
Online Access:https://doi.org/10.1186/s12575-024-00236-3

Internet

https://doi.org/10.1186/s12575-024-00236-3

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