ARF suppression by MYC but not MYCN confers increased malignancy of aggressive pediatric brain tumors

ARF suppression by MYC but not MYCN confers increased malignancy of aggressive pediatric brain tumors

CDKN2A loss and p53 mutations are rare in MYC-driven Group 3 medulloblastomas (MBs). Here the authors generated a transgenic mouse model of Group 3 MB by MYC overexpression and show that MYC suppresses ARF to drive tumorigenesis.

Bibliographic Details
Main Authors: Oliver J. Mainwaring, Holger Weishaupt, Miao Zhao, Gabriela Rosén, Anna Borgenvik, Laura Breinschmid, Annemieke D. Verbaan, Stacey Richardson, Dean Thompson, Steven C. Clifford, Rebecca M. Hill, Karl Annusver, Anders Sundström, Karl O. Holmberg, Maria Kasper, Sonja Hutter, Fredrik J. Swartling
Format: Article
Language:English
Published: Nature Portfolio 2023-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-36847-9

Internet

https://doi.org/10.1038/s41467-023-36847-9

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