GFAT1-linked TAB1 glutamylation sustains p38 MAPK activation and promotes lung cancer cell survival under glucose starvation

GFAT1-linked TAB1 glutamylation sustains p38 MAPK activation and promotes lung cancer cell survival under glucose starvation

Abstract Reprogrammed cell metabolism is deemed as one of the hallmarks of cancer. Hexosamine biosynthesis pathway (HBP) acts as an “energy sensor” in cells to regulate metabolic fluxes. Glutamine-fructose-6-phosphate amidotransferase 1 (GFAT1), the rate-limiting enzyme of HBP, is broadly found with...

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Bibliographic Details
Main Authors: Shupei Wei, Qin Zhao, Ke Zheng, Peiying Liu, Nannan Sha, Yingzi Li, Chunmin Ma, Jingjie Li, Lingang Zhuo, Guanxin Liu, Wenhua Liang, Yuhui Jiang, Tao Chen, Nanshan Zhong
Format: Article
Language:English
Published: Nature Publishing Group 2022-08-01
Series:Cell Discovery
Online Access:https://doi.org/10.1038/s41421-022-00423-0

Internet

https://doi.org/10.1038/s41421-022-00423-0

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