Single cell RNA-sequencing profiling to improve the translation between human IBD and in vivo models

Single cell RNA-sequencing profiling to improve the translation between human IBD and in vivo models

Inflammatory bowel disease (IBD) is an umbrella term for two conditions (Crohn’s Disease and Ulcerative Colitis) that is characterized by chronic inflammation of the gastrointestinal tract. The use of pre-clinical animal models has been invaluable for the understanding of potential disease mechanism...

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Bibliographic Details
Main Authors: Erik P. Karmele, Ana Laura Moldoveanu, Irem Kaymak, Bat-Erdene Jugder, Rebecca L. Ursin, Kyle J. Bednar, Daniele Corridoni, Tatiana Ort
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Immunology
Subjects:
pre-clinical models
Inflammatory bowel disease (IBD)
single cell RNA-sequencing (scRNA-seq)
epithelial cell
stromal cell
immune cell
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1291990/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1291990/full

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