Glutaminase 1 deficiency confined in forebrain neurons causes autism spectrum disorder-like behaviors

Glutaminase 1 deficiency confined in forebrain neurons causes autism spectrum disorder-like behaviors

Summary: An abnormal glutamate signaling pathway has been proposed in the mechanisms of autism spectrum disorder (ASD). However, less is known about the involvement of alterations of glutaminase 1 (GLS1) in the pathophysiology of ASD. We show that the transcript level of GLS1 is significantly decrea...

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Bibliographic Details
Main Authors: Chenhui Ji, Yalin Tang, Yanyan Zhang, Xiaoyan Huang, Congcong Li, Yuhong Yang, Qihui Wu, Xiaohuan Xia, Qingyuan Cai, Xin-Rui Qi, Jialin C. Zheng
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Cell Reports
Subjects:
CP: Neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723007234

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http://www.sciencedirect.com/science/article/pii/S2211124723007234

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