Fibrinogen Mitigates Prion-Mediated Platelet Activation and Neuronal Cell Toxicity

Fibrinogen Mitigates Prion-Mediated Platelet Activation and Neuronal Cell Toxicity

Prion peptide (PrP) misfolds to infectious scrapie isoform, the β pleat-rich insoluble fibrils responsible for neurodegeneration and fatal conformational diseases in humans. The amino acid sequence 106–126 from prion proteins, PrP(106–126), is highly amyloidogenic and implicated in prion-induced pat...

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Bibliographic Details
Main Authors: Deepa Gautam, Jyotsna Kailashiya, Arundhati Tiwari, Rameshwar Nath Chaurasia, Gowtham K. Annarapu, Prasenjit Guchhait, Debabrata Dash
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
platelet-derived extracellular vesicles
calpain activity
intracellular calcium
neuronal cell toxicity
mitochondrial membrane potential
fibrinolysis
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.834016/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2022.834016/full

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