Cryptic genetic variation shapes the adaptive evolutionary potential of enzymes

Cryptic genetic variation shapes the adaptive evolutionary potential of enzymes

Genetic variation among orthologous proteins can cause cryptic phenotypic properties that only manifest in changing environments. Such variation may impact the evolvability of proteins, but the underlying molecular basis remains unclear. Here, we performed comparative directed evolution of four orth...

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Bibliographic Details
Main Authors: Florian Baier, Nansook Hong, Gloria Yang, Anna Pabis, Charlotte M Miton, Alexandre Barrozo, Paul D Carr, Shina CL Kamerlin, Colin J Jackson, Nobuhiko Tokuriki
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-02-01
Series:eLife
Subjects:
protein evolution
evolvability
molecular mechanisms of evolution
enzyme
enzyme promiscuity
Online Access:https://elifesciences.org/articles/40789

Internet

https://elifesciences.org/articles/40789

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