Cryptic genetic variation shapes the adaptive evolutionary potential of enzymes
Genetic variation among orthologous proteins can cause cryptic phenotypic properties that only manifest in changing environments. Such variation may impact the evolvability of proteins, but the underlying molecular basis remains unclear. Here, we performed comparative directed evolution of four orth...
Main Authors: | , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2019-02-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/40789 |