TLR7 activation by imiquimod worsens glycemic control in female FVB/N mice consuming a high‐fat diet

TLR7 activation by imiquimod worsens glycemic control in female FVB/N mice consuming a high‐fat diet

Abstract Toll‐like receptor‐7 (TLR7) activation promotes autoimmunity, and metabolic syndrome (MetS) is a common comorbidity in patients with autoimmune disease. We previously demonstrated hyperinsulinemia in TLR7 agonist imiquimod (IMQ)‐treated, high‐fat diet (HFD)‐fed female C57BL/6 mice. Since mo...

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Bibliographic Details
Main Authors: Rahul M. Kakalij, Del L. Dsouza, LiGyeom Ha, Erika I. Boesen
Format: Article
Language:English
Published: Wiley 2024-02-01
Series:Physiological Reports
Subjects:
autoimmunity
hyperglycemia
imiquimod
metabolic syndrome
toll‐like receptor 7
Online Access:https://doi.org/10.14814/phy2.15949

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