Camptothecin Effectively Regulates Germline Differentiation through Bam–Cyclin A Axis in <i>Drosophila melanogaster</i>
Camptothecin (CPT), first isolated from Chinese tree <i>Camptotheca acuminate</i>, produces rapid and prolonged inhibition of DNA synthesis and induction of DNA damage by targeting topoisomerase I (top1), which is highly activated in cancer cells. CPT thus exhibits remarkable anticancer...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-01-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/2/1617 |