Neutrophil Cytosolic Factor 1 in Dendritic Cells Promotes Autoreactive CD8+ T Cell Activation via Cross-Presentation in Type 1 Diabetes

Neutrophil Cytosolic Factor 1 in Dendritic Cells Promotes Autoreactive CD8+ T Cell Activation via Cross-Presentation in Type 1 Diabetes

Aims: Reactive oxygen species (ROS) are critical in driving the onset of type 1 diabetes (T1D). Ablation of ROS derived from phagocytic NADPH oxidase 2 is protective against autoimmune diabetes in non-obese diabetic (NOD) mice. However, the mechanisms of NADPH oxidase 2-derived ROS in T1D pathogenes...

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Bibliographic Details
Main Authors: Chao Liu, Robert L. Whitener, Andrea Lin, Yuan Xu, Jing Chen, Alexei Savinov, Jennifer W. Leiding, Mark A. Wallet, Clayton E. Mathews
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Immunology
Subjects:
Reactive oxygen species
Ncf1
NADPH oxidase 2
type 1 diabetes
dendritic cell
cross-presentation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00952/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00952/full

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