Polymorphisms in Glutathione S-Transferase (<i>GST</i>) Genes Modify the Effect of Exposure to Maternal Smoking Metabolites in Pregnancy and Offspring DNA Methylation

Polymorphisms in Glutathione S-Transferase (<i>GST</i>) Genes Modify the Effect of Exposure to Maternal Smoking Metabolites in Pregnancy and Offspring DNA Methylation

Maternal smoking in pregnancy (MSP) affects the offspring’s DNA methylation (DNAm). There is a lack of knowledge regarding individual differences in susceptibility to exposure to MSP. Glutathione S-transferase (<i>GST</i>) genes are involved in protection against harmful oxidants such as...

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Bibliographic Details
Main Authors: Parnian Kheirkhah Rahimabad, A. Daniel Jones, Hongmei Zhang, Su Chen, Yu Jiang, Susan Ewart, John W. Holloway, Hasan Arshad, Shakiba Eslamimehr, Robert Bruce, Wilfried Karmaus
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Genes
Subjects:
smoking
pregnancy
DNA methylation
genetic polymorphism
glutathione S-transferase
Online Access:https://www.mdpi.com/2073-4425/14/8/1644

Internet

https://www.mdpi.com/2073-4425/14/8/1644

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