A glycine-rich PE_PGRS protein governs mycobacterial actin-based motility
Mycobacterium marinum, a close relative of Mycobacterium tuberculosis, polymerizes host actin at the bacterial surface to drive intracellular movement and cell-to-cell spread during infection. Here, Hill & Welch identify an M. marinum surface protein that binds to and activates the host protein...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-31333-0 |
| _version_ | 1811235584176291840 |
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| author | Norbert S. Hill Matthew D. Welch |
| author_facet | Norbert S. Hill Matthew D. Welch |
| author_sort | Norbert S. Hill |
| collection | DOAJ |
| description | Mycobacterium marinum, a close relative of Mycobacterium tuberculosis, polymerizes host actin at the bacterial surface to drive intracellular movement and cell-to-cell spread during infection. Here, Hill & Welch identify an M. marinum surface protein that binds to and activates the host protein NWASP to stimulate actin polymerization and drive bacterial actin-based motility. |
| first_indexed | 2024-04-12T11:54:28Z |
| format | Article |
| id | doaj.art-15e5e84ee37d4f1d89a37393022c3624 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-12T11:54:28Z |
| publishDate | 2022-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-15e5e84ee37d4f1d89a37393022c36242022-12-22T03:34:02ZengNature PortfolioNature Communications2041-17232022-06-0113111310.1038/s41467-022-31333-0A glycine-rich PE_PGRS protein governs mycobacterial actin-based motilityNorbert S. Hill0Matthew D. Welch1Department of Molecular and Cell Biology, University of CaliforniaDepartment of Molecular and Cell Biology, University of CaliforniaMycobacterium marinum, a close relative of Mycobacterium tuberculosis, polymerizes host actin at the bacterial surface to drive intracellular movement and cell-to-cell spread during infection. Here, Hill & Welch identify an M. marinum surface protein that binds to and activates the host protein NWASP to stimulate actin polymerization and drive bacterial actin-based motility.https://doi.org/10.1038/s41467-022-31333-0 |
| spellingShingle | Norbert S. Hill Matthew D. Welch A glycine-rich PE_PGRS protein governs mycobacterial actin-based motility Nature Communications |
| title | A glycine-rich PE_PGRS protein governs mycobacterial actin-based motility |
| title_full | A glycine-rich PE_PGRS protein governs mycobacterial actin-based motility |
| title_fullStr | A glycine-rich PE_PGRS protein governs mycobacterial actin-based motility |
| title_full_unstemmed | A glycine-rich PE_PGRS protein governs mycobacterial actin-based motility |
| title_short | A glycine-rich PE_PGRS protein governs mycobacterial actin-based motility |
| title_sort | glycine rich pe pgrs protein governs mycobacterial actin based motility |
| url | https://doi.org/10.1038/s41467-022-31333-0 |
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