Identification of neoantigen-specific T cells and their targets: implications for immunotherapy of head and neck squamous cell carcinoma

Identification of neoantigen-specific T cells and their targets: implications for immunotherapy of head and neck squamous cell carcinoma

To develop a practically applicable method for T-cell receptor (TCR)-engineered T cell immunotherapy targeting neoantigens, we have been attempting to identify neoantigen-specific T cell receptors (TCRs) and establish TCR-engineered T cells in a 3–4-month period. In this study, we report the charact...

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Bibliographic Details
Main Authors: Lili Ren, Matthias Leisegang, Boya Deng, Tatsuo Matsuda, Kazuma Kiyotani, Taigo Kato, Makiko Harada, Jae-Hyun Park, Vassiliki Saloura, Tanguy Seiwert, Everett Vokes, Nishant Agrawal, Yusuke Nakamura
Format: Article
Language:English
Published: Taylor & Francis Group 2019-04-01
Series:OncoImmunology
Subjects:
head and neck squamous cell carcinoma (hnscc)
t cell receptor (tcr)
adoptive t cell therapy
neoantigen
cytotoxic t lymphocyte (ctl)
engineered t cells
Online Access:http://dx.doi.org/10.1080/2162402X.2019.1568813

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http://dx.doi.org/10.1080/2162402X.2019.1568813

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