Identification of early-onset photoreceptor degeneration in transgenic mouse models of Alzheimer's disease

Summary: Light sensitivity of the vertebrate retina relies on the integrity of photoreceptors, including rods and cones. Research in patients with Alzheimer's disease (AD) and in AD transgenic mice reports that accumulated amyloid-β (Aβ) plaques in the retina are toxic to retinal neurons. Moreo...

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Bibliographic Details
Main Authors: Jie Zhang, Feng Gao, Yuqian Ma, Tian Xue, Yong Shen
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221012967