Unexplained mismatch repair deficiency: Case closed

Unexplained mismatch repair deficiency: Case closed

Summary: To identify Lynch syndrome (LS) carriers, DNA mismatch repair (MMR) immunohistochemistry (IHC) is performed on colorectal cancers (CRCs). Upon subsequent LS diagnostics, MMR deficiency (MMRd) sometimes remains unexplained (UMMRd). Recently, the importance of complete LS diagnostics to expla...

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Bibliographic Details
Main Authors: Ellis L. Eikenboom, Sarah Moen, Lotte van Leeuwen, Willemina R.R. Geurts-Giele, Carli M.J. Tops, Tjakko J. van Ham, Winand N.M. Dinjens, Hendrikus J. Dubbink, Manon C.W. Spaander, Anja Wagner
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:HGG Advances
Subjects:
Lynch syndrome
colorectal cancer
unexplained mismatch repair deficiency
UMMRd
genetic testing
Online Access:http://www.sciencedirect.com/science/article/pii/S2666247722000847

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http://www.sciencedirect.com/science/article/pii/S2666247722000847

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