Pancreas-Specific Sirt1-Deficiency in Mice Compromises Beta-Cell Function without Development of Hyperglycemia.

Pancreas-Specific Sirt1-Deficiency in Mice Compromises Beta-Cell Function without Development of Hyperglycemia.

Sirtuin 1 (Sirt1) has been reported to be a critical positive regulator of glucose-stimulated insulin secretion in pancreatic beta-cells. The effects on islet cells and blood glucose levels when Sirt1 is deleted specifically in the pancreas are still unclear.This study examined islet glucose respons...

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Bibliographic Details
Main Authors: Andreia V Pinho, Mohammed Bensellam, Elke Wauters, Maxine Rees, Marc Giry-Laterriere, Amanda Mawson, Le Quan Ly, Andrew V Biankin, Jianmin Wu, D Ross Laybutt, Ilse Rooman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4457418?pdf=render

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http://europepmc.org/articles/PMC4457418?pdf=render

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