Anti-Proliferative and Pro-Apoptotic Effects of Short-Term Inhibition of Telomerase In Vivo and in Human Malignant B Cells Xenografted in Zebrafish

Anti-Proliferative and Pro-Apoptotic Effects of Short-Term Inhibition of Telomerase In Vivo and in Human Malignant B Cells Xenografted in Zebrafish

Besides its canonical role in stabilizing telomeres, telomerase reverse transcriptase (TERT) may promote tumor growth/progression through extra-telomeric functions. Our previous in vitro studies demonstrated that short-term TERT inhibition by BIBR1532 (BIBR), an inhibitor of TERT catalytic activity,...

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Bibliographic Details
Main Authors: Silvia Giunco, Manuela Zangrossi, Francesca Dal Pozzolo, Andrea Celeghin, Giovanni Ballin, Maria Raffaella Petrara, Aamir Amin, Francesco Argenton, Miguel Godinho Ferreira, Anita De Rossi
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Cancers
Subjects:
TERT/telomerase
B-cell malignancies
new therapeutic approach
zebrafish
xenograft
Online Access:https://www.mdpi.com/2072-6694/12/8/2052

Internet

https://www.mdpi.com/2072-6694/12/8/2052

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