Genistein Ameliorates Renal Fibrosis Through Regulation Snail via m6A RNA Demethylase ALKBH5

Genistein Ameliorates Renal Fibrosis Through Regulation Snail via m6A RNA Demethylase ALKBH5

Renal tubule-interstitial fibrosis is related to chronic kidney disease progression and a typical feature of the aging kidney. Epigenetic modifications of fibrosis-prone genes regulate the development of renal fibrosis. As a kind of “epigenetic diet”, soy isoflavone genistein was reported to have re...

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Bibliographic Details
Main Authors: Yichun Ning, Jing Chen, Yiqin Shi, Nana Song, Xiaofang Yu, Yi Fang, Xiaoqiang Ding
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Pharmacology
Subjects:
renal fibrosis
genistein
RNA methylation
epithelial-to-mesenchymal transition
ALKBH5
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.579265/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2020.579265/full

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