Enteroaggregative E. coli Adherence to Human Heparan Sulfate Proteoglycans Drives Segment and Host Specific Responses to Infection.

Enteroaggregative Escherichia coli (EAEC) is a significant cause of acute and chronic diarrhea, foodborne outbreaks, infections of the immunocompromised, and growth stunting in children in developing nations. There is no vaccine and resistance to antibiotics is rising. Unlike related E. coli pathoty...

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Main Authors: Anubama Rajan, Matthew J Robertson, Hannah E Carter, Nina M Poole, Justin R Clark, Sabrina I Green, Zachary K Criss, Boyang Zhao, Umesh Karandikar, Yikun Xing, Mar Margalef-Català, Nikhil Jain, Reid L Wilson, Fan Bai, Joseph M Hyser, Joseph Petrosino, Noah F Shroyer, Sarah E Blutt, Cristian Coarfa, Xuezheng Song, Bv Venkataram Prasad, Manuel R Amieva, Jane Grande-Allen, Mary K Estes, Pablo C Okhuysen, Anthony W Maresso
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-09-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1008851