High Glucose Concentration Stimulates NHE-1 Activity in Distal Nephron Cells: the Role of the Mek/Erk1/2/p90RSK and p38MAPK Signaling Pathways

Aims: In models of diabetes, distal nephron cells contribute to glucose uptake and oxidation. How these cells contribute to the use of glucose for the regulation of H+ extrusion remains unknown. We used Madin-Darby Canine Kidney (MDCK) cells to investigate the effect of acute or chronic high glucose...

Full description

Bibliographic Details
Main Authors: Juliana Martins da Costa-Pessoa, Rosélia Santos Damasceno, Ubiratan Fabres Machado, Olívia Beloto-Silva, Maria Oliveira-Souza
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2014-02-01
Series:Cellular Physiology and Biochemistry
Subjects:
Online Access:http://www.karger.com/Article/FullText/356673