In-vitro biological evaluation of 3,3′,5,5′-tetramethoxy-biphenyl-4,4′-diol and molecular docking studies on trypanothione reductase and Gp63 from Leishmania amazonensis demonstrated anti-leishmania potential

In-vitro biological evaluation of 3,3′,5,5′-tetramethoxy-biphenyl-4,4′-diol and molecular docking studies on trypanothione reductase and Gp63 from Leishmania amazonensis demonstrated anti-leishmania potential

Abstract Available treatments for leishmaniasis have been widely used since the 1940s but come at a high cost, variable efficacy, high toxicity, and adverse side-effects. 3,3′,5,5′-Tetramethoxy-biphenyl-4,4′-diol (TMBP) was synthesized through laccase-catalysis of 2,6-dimethoxyphenol and displayed a...

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Bibliographic Details
Main Authors: Jéseka G. Schirmann, Bruna T. S. Bortoleti, Manoela D. Gonçalves, Fernanda Tomiotto-Pellissier, Priscila G. Camargo, Milena M. Miranda-Sapla, Camilo H. S. Lima, Marcelle L. F. Bispo, Idessania N. Costa, Ivete Conchon-Costa, Wander R. Pavanelli, Robert F. H. Dekker, Aneli M. Barbosa-Dekker
Format: Article
Language:English
Published: Nature Portfolio 2023-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-34124-9

Internet

https://doi.org/10.1038/s41598-023-34124-9

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