A Novel, Pan-PDE Inhibitor Exerts Anti-Fibrotic Effects in Human Lung Fibroblasts via Inhibition of TGF-β Signaling and Activation of cAMP/PKA Signaling

A Novel, Pan-PDE Inhibitor Exerts Anti-Fibrotic Effects in Human Lung Fibroblasts via Inhibition of TGF-β Signaling and Activation of cAMP/PKA Signaling

Phosphodiesterase (PDE) inhibitors are currently a widespread and extensively studied group of anti-inflammatory and anti-fibrotic compounds which may find use in the treatment of numerous lung diseases, including asthma and chronic obstructive pulmonary disease. Several PDE inhibitors are currently...

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Bibliographic Details
Main Authors: Katarzyna Wójcik-Pszczoła, Grażyna Chłoń-Rzepa, Agnieszka Jankowska, Marietta Ślusarczyk, Paweł E Ferdek, Agnieszka A Kusiak, Artur Świerczek, Krzysztof Pociecha, Paulina Koczurkiewicz-Adamczyk, Elżbieta Wyska, Elżbieta Pękala, Reinoud Gosens
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:International Journal of Molecular Sciences
Subjects:
asthma
COPD
myofibroblasts
airway remodeling
fibroblast-to-myofibroblast transition
TGF-β
Online Access:https://www.mdpi.com/1422-0067/21/11/4008

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https://www.mdpi.com/1422-0067/21/11/4008

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