Amino Acid Substitutions in Positions 385 and 393 of the Hydrophobic Region of VP4 May Be Associated with Rotavirus Attenuation and Cell Culture Adaptation

Amino Acid Substitutions in Positions 385 and 393 of the Hydrophobic Region of VP4 May Be Associated with Rotavirus Attenuation and Cell Culture Adaptation

Rotaviruses (RVs) are the leading cause of the acute viral gastroenteritis in young children and livestock animals worldwide. Although live attenuated vaccines have been applied to control RV infection for many years, the underlying mechanisms of RV attenuation following cell culture adaption are un...

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Bibliographic Details
Main Authors: Yusheng Guo, David E. Wentworth, Karla M. Stucker, Rebecca A. Halpin, Ham Ching Lam, Douglas Marthaler, Linda J. Saif, Anastasia N. Vlasova
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Viruses
Subjects:
rotavirus
VP4
attenuation
vaccine
cell culture adaptation
Online Access:https://www.mdpi.com/1999-4915/12/4/408

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https://www.mdpi.com/1999-4915/12/4/408

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