Kinome-Wide RNA Interference Screening Identifies Mitogen-Activated Protein Kinases and Phosphatidylinositol Metabolism as Key Factors for Rabies Virus Infection

Kinome-Wide RNA Interference Screening Identifies Mitogen-Activated Protein Kinases and Phosphatidylinositol Metabolism as Key Factors for Rabies Virus Infection

ABSTRACT Throughout the rabies virus (RABV) infectious cycle, host-virus interactions define its capacity to replicate, escape the immune response, and spread. As phosphorylation is a key regulatory mechanism involved in most cellular processes, kinases represent a target of choice to identify host...

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Bibliographic Details
Main Authors: Benoit Besson, Seonhee Kim, Taehee Kim, Yoonae Ko, Sangchul Lee, Florence Larrous, Jihwan Song, David Shum, Regis Grailhe, Hervé Bourhy
Format: Article
Language:English
Published: American Society for Microbiology 2019-06-01
Series:mSphere
Subjects:
RNA interference
drug screening
inositol phosphate phosphatases
mitogen-activated protein kinases
rabies
Online Access:https://journals.asm.org/doi/10.1128/mSphere.00047-19

Internet

https://journals.asm.org/doi/10.1128/mSphere.00047-19

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