Peripheral origin exosomal microRNAs aggravate glymphatic system dysfunction in diabetic cognitive impairment

Peripheral origin exosomal microRNAs aggravate glymphatic system dysfunction in diabetic cognitive impairment

Cognitive dysfunction is one of the common central nervous systems (CNS) complications of diabetes mellitus, which seriously affects the quality of life of patients and results in a huge economic burden. The glymphatic system dysfunction mediated by aquaporin-4 (AQP4) loss or redistribution in periv...

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Bibliographic Details
Main Authors: Lin Zhang, Dongna Li, Pengrong Yi, Jiangwei Shi, Mengqing Guo, Qingsheng Yin, Dingbin Liu, Pengwei Zhuang, Yanjun Zhang
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Diabetic cognitive impairment
AQP4
Peripheral–central communication
Exosomal miRNAs
Central nervous system
Glymphatic system
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383523001077

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http://www.sciencedirect.com/science/article/pii/S2211383523001077

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