Peripheral origin exosomal microRNAs aggravate glymphatic system dysfunction in diabetic cognitive impairment
Cognitive dysfunction is one of the common central nervous systems (CNS) complications of diabetes mellitus, which seriously affects the quality of life of patients and results in a huge economic burden. The glymphatic system dysfunction mediated by aquaporin-4 (AQP4) loss or redistribution in periv...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-07-01
|
| Series: | Acta Pharmaceutica Sinica B |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211383523001077 |
| _version_ | 1827897716864188416 |
|---|---|
| author | Lin Zhang Dongna Li Pengrong Yi Jiangwei Shi Mengqing Guo Qingsheng Yin Dingbin Liu Pengwei Zhuang Yanjun Zhang |
| author_facet | Lin Zhang Dongna Li Pengrong Yi Jiangwei Shi Mengqing Guo Qingsheng Yin Dingbin Liu Pengwei Zhuang Yanjun Zhang |
| author_sort | Lin Zhang |
| collection | DOAJ |
| description | Cognitive dysfunction is one of the common central nervous systems (CNS) complications of diabetes mellitus, which seriously affects the quality of life of patients and results in a huge economic burden. The glymphatic system dysfunction mediated by aquaporin-4 (AQP4) loss or redistribution in perivascular astrocyte endfeet plays a crucial role in diabetes-induced cognitive impairment (DCI). However, the mechanism of AQP4 loss or redistribution in the diabetic states remains unclear. Accumulating evidence suggests that peripheral insulin resistance target tissues and CNS communication affect brain homeostasis and that exosomal miRNAs are key mediators. Glucose and lipid metabolism disorder is an important pathological feature of diabetes mellitus, and skeletal muscle, liver and adipose tissue are the key target insulin resistance organs. In this review, the changes in exosomal miRNAs induced by peripheral metabolism disorders in diabetes mellitus were systematically reviewed. We focused on exosomal miRNAs that could induce low AQP4 expression and redistribution in perivascular astrocyte endfeet, which could provide an interorgan communication pathway to illustrate the pathogenesis of DCI. Furthermore, the mechanisms of exosome secretion from peripheral insulin resistance target tissue and absorption to the CNS were summarized, which will be beneficial for proposing novel and feasible strategies to optimize DCI prevention and/or treatment in diabetic patients. |
| first_indexed | 2024-03-12T22:52:41Z |
| format | Article |
| id | doaj.art-1607264b99304b7fa65fd60c115ed0f8 |
| institution | Directory Open Access Journal |
| issn | 2211-3835 |
| language | English |
| last_indexed | 2024-03-12T22:52:41Z |
| publishDate | 2023-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Acta Pharmaceutica Sinica B |
| spelling | doaj.art-1607264b99304b7fa65fd60c115ed0f82023-07-20T04:38:25ZengElsevierActa Pharmaceutica Sinica B2211-38352023-07-0113728172825Peripheral origin exosomal microRNAs aggravate glymphatic system dysfunction in diabetic cognitive impairmentLin Zhang0Dongna Li1Pengrong Yi2Jiangwei Shi3Mengqing Guo4Qingsheng Yin5Dingbin Liu6Pengwei Zhuang7Yanjun Zhang8State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, ChinaState Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, ChinaState Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, ChinaFirst Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China; National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300193, ChinaState Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, ChinaState Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China; Haihe Laboratory of Modern Chinese Medicine, Tianjin 301617, ChinaState Key Laboratory of Medicinal Chemical Biology, Research Center for Analytical Sciences, and Tianjin Key Laboratory of Molecular Recognition and Biosensing, College of Chemistry, Nankai University, Tianjin 300071, China; Corresponding authors.State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China; Haihe Laboratory of Modern Chinese Medicine, Tianjin 301617, China; Corresponding authors.State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China; Haihe Laboratory of Modern Chinese Medicine, Tianjin 301617, China; First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China; National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300193, China; Corresponding authors.Cognitive dysfunction is one of the common central nervous systems (CNS) complications of diabetes mellitus, which seriously affects the quality of life of patients and results in a huge economic burden. The glymphatic system dysfunction mediated by aquaporin-4 (AQP4) loss or redistribution in perivascular astrocyte endfeet plays a crucial role in diabetes-induced cognitive impairment (DCI). However, the mechanism of AQP4 loss or redistribution in the diabetic states remains unclear. Accumulating evidence suggests that peripheral insulin resistance target tissues and CNS communication affect brain homeostasis and that exosomal miRNAs are key mediators. Glucose and lipid metabolism disorder is an important pathological feature of diabetes mellitus, and skeletal muscle, liver and adipose tissue are the key target insulin resistance organs. In this review, the changes in exosomal miRNAs induced by peripheral metabolism disorders in diabetes mellitus were systematically reviewed. We focused on exosomal miRNAs that could induce low AQP4 expression and redistribution in perivascular astrocyte endfeet, which could provide an interorgan communication pathway to illustrate the pathogenesis of DCI. Furthermore, the mechanisms of exosome secretion from peripheral insulin resistance target tissue and absorption to the CNS were summarized, which will be beneficial for proposing novel and feasible strategies to optimize DCI prevention and/or treatment in diabetic patients.http://www.sciencedirect.com/science/article/pii/S2211383523001077Diabetic cognitive impairmentAQP4Peripheral–central communicationExosomal miRNAsCentral nervous systemGlymphatic system |
| spellingShingle | Lin Zhang Dongna Li Pengrong Yi Jiangwei Shi Mengqing Guo Qingsheng Yin Dingbin Liu Pengwei Zhuang Yanjun Zhang Peripheral origin exosomal microRNAs aggravate glymphatic system dysfunction in diabetic cognitive impairment Acta Pharmaceutica Sinica B Diabetic cognitive impairment AQP4 Peripheral–central communication Exosomal miRNAs Central nervous system Glymphatic system |
| title | Peripheral origin exosomal microRNAs aggravate glymphatic system dysfunction in diabetic cognitive impairment |
| title_full | Peripheral origin exosomal microRNAs aggravate glymphatic system dysfunction in diabetic cognitive impairment |
| title_fullStr | Peripheral origin exosomal microRNAs aggravate glymphatic system dysfunction in diabetic cognitive impairment |
| title_full_unstemmed | Peripheral origin exosomal microRNAs aggravate glymphatic system dysfunction in diabetic cognitive impairment |
| title_short | Peripheral origin exosomal microRNAs aggravate glymphatic system dysfunction in diabetic cognitive impairment |
| title_sort | peripheral origin exosomal micrornas aggravate glymphatic system dysfunction in diabetic cognitive impairment |
| topic | Diabetic cognitive impairment AQP4 Peripheral–central communication Exosomal miRNAs Central nervous system Glymphatic system |
| url | http://www.sciencedirect.com/science/article/pii/S2211383523001077 |
| work_keys_str_mv | AT linzhang peripheraloriginexosomalmicrornasaggravateglymphaticsystemdysfunctionindiabeticcognitiveimpairment AT dongnali peripheraloriginexosomalmicrornasaggravateglymphaticsystemdysfunctionindiabeticcognitiveimpairment AT pengrongyi peripheraloriginexosomalmicrornasaggravateglymphaticsystemdysfunctionindiabeticcognitiveimpairment AT jiangweishi peripheraloriginexosomalmicrornasaggravateglymphaticsystemdysfunctionindiabeticcognitiveimpairment AT mengqingguo peripheraloriginexosomalmicrornasaggravateglymphaticsystemdysfunctionindiabeticcognitiveimpairment AT qingshengyin peripheraloriginexosomalmicrornasaggravateglymphaticsystemdysfunctionindiabeticcognitiveimpairment AT dingbinliu peripheraloriginexosomalmicrornasaggravateglymphaticsystemdysfunctionindiabeticcognitiveimpairment AT pengweizhuang peripheraloriginexosomalmicrornasaggravateglymphaticsystemdysfunctionindiabeticcognitiveimpairment AT yanjunzhang peripheraloriginexosomalmicrornasaggravateglymphaticsystemdysfunctionindiabeticcognitiveimpairment |