SNX8 Enhances Non-amyloidogenic APP Trafficking and Attenuates Aβ Accumulation and Memory Deficits in an AD Mouse

SNX8 Enhances Non-amyloidogenic APP Trafficking and Attenuates Aβ Accumulation and Memory Deficits in an AD Mouse

Dysregulation of various APP trafficking components in the endosome has been previously implicated in Alzheimer’s disease (AD). Although single nucleotide polymorphisms within the gene locus encoding the endosomal component, SNX8 have been previously associated with AD, how SNX8 levels are altered a...

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Bibliographic Details
Main Authors: Yongzhuang Xie, Mengxi Niu, Chengxiang Ji, Timothy Y. Huang, Cuilin Zhang, Ye Tian, Zhun Shi, Chen Wang, Yingjun Zhao, Hong Luo, Dan Can, Huaxi Xu, Yun-wu Zhang, Xian Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Cellular Neuroscience
Subjects:
SNX8
sorting nexins
Alzheimer’s disease
β-amyloid
β-amyloid precursor protein
APP trafficking
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00410/full

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https://www.frontiersin.org/article/10.3389/fncel.2019.00410/full

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