Ptbp2 re-expression rescues axon growth defects in Smn-deficient motoneurons

Ptbp2 re-expression rescues axon growth defects in Smn-deficient motoneurons

Spinal muscular atrophy (SMA) is a neuromuscular disorder caused by mutations or deletions in the survival motoneuron 1 (SMN1) gene, resulting in deficiency of the SMN protein that is essential for motoneuron function. Smn depletion in mice disturbs axonal RNA transport and translation, thereby cont...

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Bibliographic Details
Main Authors: Saeede Salehi, Abdolhossein Zare, Gayatri Gandhi, Michael Sendtner, Michael Briese
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-08-01
Series:Frontiers in Molecular Neuroscience
Subjects:
spinal muscular atrophy
SMN
axonal RNA transport
axonal translation
axon growth
Ptbp2
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2024.1393779/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2024.1393779/full

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