Spatial Transcriptomic and Metabolomic Landscapes of Oral Submucous Fibrosis‐Derived Oral Squamous Cell Carcinoma and its Tumor Microenvironment

Spatial Transcriptomic and Metabolomic Landscapes of Oral Submucous Fibrosis‐Derived Oral Squamous Cell Carcinoma and its Tumor Microenvironment

Abstract In South and Southeast Asia, the habit of chewing betel nuts is prevalent, which leads to oral submucous fibrosis (OSF). OSF is a well‐established precancerous lesion, and a portion of OSF cases eventually progress to oral squamous cell carcinoma (OSCC). However, the specific molecular mech...

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Bibliographic Details
Main Authors: Yuan Zhi, Qian Wang, Moxin Zi, Shanshan Zhang, Junshang Ge, Keyue Liu, Linsong Lu, Chunmei Fan, Qijia Yan, Lei Shi, Pan Chen, Songqing Fan, Qianjin Liao, Can Guo, Fuyan Wang, Zhaojian Gong, Wei Xiong, Zhaoyang Zeng
Format: Article
Language:English
Published: Wiley 2024-03-01
Series:Advanced Science
Subjects:
oral squamous cell carcinoma (OSCC)
oral submucous fibrosis (OSF)
polyamine metabolism
spatial metabolomics
spatial transcriptomics
tumor microenvironment
Online Access:https://doi.org/10.1002/advs.202306515

Internet

https://doi.org/10.1002/advs.202306515

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