Artemis inhibition as a therapeutic strategy for acute lymphoblastic leukemia

Artemis inhibition as a therapeutic strategy for acute lymphoblastic leukemia

As effective therapies for relapse and refractory B-cell acute lymphoblastic leukemia (B-ALL) remain problematic, novel therapeutic strategies are needed. Artemis is a key endonuclease in V(D)J recombination and nonhomologous end joining (NHEJ) of DNA double-strand break (DSB) repair. Inhibition of...

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Bibliographic Details
Main Authors: Heather A. Ogana, Samantha Hurwitz, Chih-Lin Hsieh, Huimin Geng, Markus Müschen, Deepa Bhojwani, Mark A. Wolf, James Larocque, Michael R. Lieber, Yong Mi Kim
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
acute lymphoblastic leukemia
ARTEMIS
pharmacological inhibition
proliferation
V(D)J recombination
DNA hairpin
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2023.1134121/full

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https://www.frontiersin.org/articles/10.3389/fcell.2023.1134121/full

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