Discovery and mechanism studies of a novel ATG4B inhibitor Ebselen by drug repurposing and its anti-colorectal cancer effects in mice

Discovery and mechanism studies of a novel ATG4B inhibitor Ebselen by drug repurposing and its anti-colorectal cancer effects in mice

Highlights 1. High-throughput screening of ATG4B inhibitors based on FDA-approved drug library 2. Ebselen can covalently bind to ATG4B at Cys74 3. Ebselen can promote ATG4B oligomerization at Cys292 and Cys361 4. Ebselen suppresses the growth of colorectal cancer cells and xenograft tumors via ATG4B...

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Bibliographic Details
Main Authors: Huazhong Xie, Pengfei Qiang, Yao Wang, Fan Xia, Peiqing Liu, Min Li
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Cell & Bioscience
Subjects:
ATG4B inhibitor
Autophagy
Colorectal cancer
FDA-approved drug
High- throughput screening
Protein oligomerization
Online Access:https://doi.org/10.1186/s13578-022-00944-x

Internet

https://doi.org/10.1186/s13578-022-00944-x

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