Proteome wide association studies of LRRK2 variants identify novel causal and druggable proteins for Parkinson’s disease

Proteome wide association studies of LRRK2 variants identify novel causal and druggable proteins for Parkinson’s disease

Abstract Common and rare variants in the LRRK2 locus are associated with Parkinson’s disease (PD) risk, but the downstream effects of these variants on protein levels remain unknown. We performed comprehensive proteogenomic analyses using the largest aptamer-based CSF proteomics study to date (7006...

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Bibliographic Details
Main Authors: Bridget Phillips, Daniel Western, Lihua Wang, Jigyasha Timsina, Yichen Sun, Priyanka Gorijala, Chengran Yang, Anh Do, Niko-Petteri Nykänen, Ignacio Alvarez, Miquel Aguilar, Pau Pastor, John C. Morris, Suzanne E. Schindler, Anne M. Fagan, Raquel Puerta, Pablo García-González, Itziar de Rojas, Marta Marquié, Mercè Boada, Agustin Ruiz, Joel S. Perlmutter, Dominantly Inherited Alzheimer Network (DIAN) Consortia, Laura Ibanez, Richard J. Perrin, Yun Ju Sung, Carlos Cruchaga
Format: Article
Language:English
Published: Nature Portfolio 2023-07-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-023-00555-4

Internet

https://doi.org/10.1038/s41531-023-00555-4

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