Discovery of Novel Small-Molecule Inhibitors of PD-1/PD-L1 Interaction via Structural Simplification Strategy

Discovery of Novel Small-Molecule Inhibitors of PD-1/PD-L1 Interaction via Structural Simplification Strategy

Blockade of the programmed cell death 1 (PD-1)/programmed cell death-ligand 1 (PD-L1) interaction is currently the focus in the field of cancer immunotherapy, and so far, several monoclonal antibodies (mAbs) have achieved encouraging outcomes in cancer treatment. Despite this achievement, mAbs-based...

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Bibliographic Details
Main Authors: Hongbo Zhang, Yu Xia, Chunqiu Yu, Huijie Du, Jinchang Liu, Hui Li, Shihui Huang, Qihua Zhu, Yungen Xu, Yi Zou
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Molecules
Subjects:
small molecule PD-1/PD-L1 inhibitor
PD-1/PD-L1
structural simplification strategy
Online Access:https://www.mdpi.com/1420-3049/26/11/3347

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https://www.mdpi.com/1420-3049/26/11/3347

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