Comprehensive genomics in androgen receptor-dependent castration-resistant prostate cancer identifies an adaptation pathway mediated by opioid receptor kappa 1

Comprehensive genomics in androgen receptor-dependent castration-resistant prostate cancer identifies an adaptation pathway mediated by opioid receptor kappa 1

Through comparative genomics using PDX models of androgen-dependent (AD) and androgen-resistant (AR) tumors, Makino et al. identify opioid receptor kappa 1 (OPRK1) as being associated with castration-resistance. Loss of OPRK1 function delays castration-resistance and inhibits castration-resistant gr...

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Bibliographic Details
Main Authors: Yuki Makino, Yuki Kamiyama, J. B. Brown, Toshiya Tanaka, Ryusuke Murakami, Yuki Teramoto, Takayuki Goto, Shusuke Akamatsu, Naoki Terada, Takahiro Inoue, Tatsuhiko Kodama, Osamu Ogawa, Takashi Kobayashi
Format: Article
Language:English
Published: Nature Portfolio 2022-04-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-022-03227-w

Internet

https://doi.org/10.1038/s42003-022-03227-w

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