Comprehensive genomics in androgen receptor-dependent castration-resistant prostate cancer identifies an adaptation pathway mediated by opioid receptor kappa 1
Through comparative genomics using PDX models of androgen-dependent (AD) and androgen-resistant (AR) tumors, Makino et al. identify opioid receptor kappa 1 (OPRK1) as being associated with castration-resistance. Loss of OPRK1 function delays castration-resistance and inhibits castration-resistant gr...
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Bibliographic Details
| Main Authors: |
Yuki Makino,
Yuki Kamiyama,
J. B. Brown,
Toshiya Tanaka,
Ryusuke Murakami,
Yuki Teramoto,
Takayuki Goto,
Shusuke Akamatsu,
Naoki Terada,
Takahiro Inoue,
Tatsuhiko Kodama,
Osamu Ogawa,
Takashi Kobayashi |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2022-04-01
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| Series: | Communications Biology
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| Online Access: | https://doi.org/10.1038/s42003-022-03227-w
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