Comprehensive genomics in androgen receptor-dependent castration-resistant prostate cancer identifies an adaptation pathway mediated by opioid receptor kappa 1
Through comparative genomics using PDX models of androgen-dependent (AD) and androgen-resistant (AR) tumors, Makino et al. identify opioid receptor kappa 1 (OPRK1) as being associated with castration-resistance. Loss of OPRK1 function delays castration-resistance and inhibits castration-resistant gr...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-04-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-022-03227-w |
| _version_ | 1819025061694144512 |
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| author | Yuki Makino Yuki Kamiyama J. B. Brown Toshiya Tanaka Ryusuke Murakami Yuki Teramoto Takayuki Goto Shusuke Akamatsu Naoki Terada Takahiro Inoue Tatsuhiko Kodama Osamu Ogawa Takashi Kobayashi |
| author_facet | Yuki Makino Yuki Kamiyama J. B. Brown Toshiya Tanaka Ryusuke Murakami Yuki Teramoto Takayuki Goto Shusuke Akamatsu Naoki Terada Takahiro Inoue Tatsuhiko Kodama Osamu Ogawa Takashi Kobayashi |
| author_sort | Yuki Makino |
| collection | DOAJ |
| description | Through comparative genomics using PDX models of androgen-dependent (AD) and androgen-resistant (AR) tumors, Makino et al. identify opioid receptor kappa 1 (OPRK1) as being associated with castration-resistance. Loss of OPRK1 function delays castration-resistance and inhibits castration-resistant growth of prostate cancer cells in culture and in vivo, suggesting OPRK1 as a therapeutic target. |
| first_indexed | 2024-12-21T05:04:42Z |
| format | Article |
| id | doaj.art-1616ee52299048a1a15f3ff943dad8e7 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-12-21T05:04:42Z |
| publishDate | 2022-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-1616ee52299048a1a15f3ff943dad8e72022-12-21T19:15:09ZengNature PortfolioCommunications Biology2399-36422022-04-015111410.1038/s42003-022-03227-wComprehensive genomics in androgen receptor-dependent castration-resistant prostate cancer identifies an adaptation pathway mediated by opioid receptor kappa 1Yuki Makino0Yuki Kamiyama1J. B. Brown2Toshiya Tanaka3Ryusuke Murakami4Yuki Teramoto5Takayuki Goto6Shusuke Akamatsu7Naoki Terada8Takahiro Inoue9Tatsuhiko Kodama10Osamu Ogawa11Takashi Kobayashi12Department of Urology, Kyoto University Graduate School of MedicineDepartment of Urology, Kyoto University Graduate School of MedicineLaboratory of Molecular Biosciences, Kyoto University Graduate School of MedicineResearch Center for Advanced Science and Technology, The University of TokyoDepartment of Gynecology and Obstetrics, Kyoto University Graduate School of MedicineDepartment of Diagnostic Pathology, Kyoto University Graduate School of MedicineDepartment of Urology, Kyoto University Graduate School of MedicineDepartment of Urology, Kyoto University Graduate School of MedicineDepartment of Urology, Kyoto University Graduate School of MedicineDepartment of Urology, Kyoto University Graduate School of MedicineResearch Center for Advanced Science and Technology, The University of TokyoDepartment of Urology, Kyoto University Graduate School of MedicineDepartment of Urology, Kyoto University Graduate School of MedicineThrough comparative genomics using PDX models of androgen-dependent (AD) and androgen-resistant (AR) tumors, Makino et al. identify opioid receptor kappa 1 (OPRK1) as being associated with castration-resistance. Loss of OPRK1 function delays castration-resistance and inhibits castration-resistant growth of prostate cancer cells in culture and in vivo, suggesting OPRK1 as a therapeutic target.https://doi.org/10.1038/s42003-022-03227-w |
| spellingShingle | Yuki Makino Yuki Kamiyama J. B. Brown Toshiya Tanaka Ryusuke Murakami Yuki Teramoto Takayuki Goto Shusuke Akamatsu Naoki Terada Takahiro Inoue Tatsuhiko Kodama Osamu Ogawa Takashi Kobayashi Comprehensive genomics in androgen receptor-dependent castration-resistant prostate cancer identifies an adaptation pathway mediated by opioid receptor kappa 1 Communications Biology |
| title | Comprehensive genomics in androgen receptor-dependent castration-resistant prostate cancer identifies an adaptation pathway mediated by opioid receptor kappa 1 |
| title_full | Comprehensive genomics in androgen receptor-dependent castration-resistant prostate cancer identifies an adaptation pathway mediated by opioid receptor kappa 1 |
| title_fullStr | Comprehensive genomics in androgen receptor-dependent castration-resistant prostate cancer identifies an adaptation pathway mediated by opioid receptor kappa 1 |
| title_full_unstemmed | Comprehensive genomics in androgen receptor-dependent castration-resistant prostate cancer identifies an adaptation pathway mediated by opioid receptor kappa 1 |
| title_short | Comprehensive genomics in androgen receptor-dependent castration-resistant prostate cancer identifies an adaptation pathway mediated by opioid receptor kappa 1 |
| title_sort | comprehensive genomics in androgen receptor dependent castration resistant prostate cancer identifies an adaptation pathway mediated by opioid receptor kappa 1 |
| url | https://doi.org/10.1038/s42003-022-03227-w |
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