Autoreactive B cells in rheumatoid arthritis include mainly activated CXCR3+ memory B cells and plasmablasts

Many autoimmune diseases (AIDs) are characterized by the persistence of autoreactive B cell responses, which have been directly implicated in disease pathogenesis. How and why these cells are generated or how they are maintained for years is largely unknown. Rheumatoid arthritis (RA) is among the mo...

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Bibliographic Details
Main Authors: Sanne Reijm, Joanneke C. Kwekkeboom, Nienke J. Blomberg, Jolien Suurmond, Diane van der Woude, René E.M. Toes, Hans U. Scherer
Format: Article
Language:English
Published: American Society for Clinical investigation 2023-10-01
Series:JCI Insight
Subjects:
Online Access:https://doi.org/10.1172/jci.insight.172006