Targeting ABCC6 in Mesenchymal Stem Cells: Impairment of Mature Adipocyte Lipid Homeostasis

Targeting ABCC6 in Mesenchymal Stem Cells: Impairment of Mature Adipocyte Lipid Homeostasis

Mutations in ABCC6, an ATP-binding cassette transporter with a so far unknown substrate mainly expressed in the liver and kidney, cause pseudoxanthoma elasticum (PXE). Symptoms of PXE in patients originate from the calcification of elastic fibers in the skin, eye, and vessels. Previous studies sugge...

Full description

Bibliographic Details
Main Authors: Ricarda Plümers, Michel R. Osterhage, Christopher Lindenkamp, Cornelius Knabbe, Doris Hendig
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:International Journal of Molecular Sciences
Subjects:
ABCC6
adipogenesis
lipid homeostasis
mesenchymal stem cells
metabolic disease
pseudoxanthoma elasticum
Online Access:https://www.mdpi.com/1422-0067/23/16/9218

Internet

https://www.mdpi.com/1422-0067/23/16/9218

Similar Items