Targeting C-myc G-Quadruplex: Dual Recognition by Aminosugar-Bisbenzimidazoles with Varying Linker Lengths

Targeting C-myc G-Quadruplex: Dual Recognition by Aminosugar-Bisbenzimidazoles with Varying Linker Lengths

G-quadruplexes are therapeutically important biological targets. In this report, we present biophysical studies of neomycin-Hoechst 33258 conjugates binding to a G-quadruplex derived from the C-myc promoter sequence. Our studies indicate that conjugation of neomycin to a G-quadruplex binder, Hoechs...

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Bibliographic Details
Main Authors: Nihar Ranjan, Dev P. Arya
Format: Article
Language:English
Published: MDPI AG 2013-11-01
Series:Molecules
Subjects:
G-quadruplex
neomycin
Hoechst 33258
oncogenes
FID
C-myc
Online Access:http://www.mdpi.com/1420-3049/18/11/14228

Internet

http://www.mdpi.com/1420-3049/18/11/14228

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