Mycobacterium tuberculosis PPE51 Inhibits Autophagy by Suppressing Toll-Like Receptor 2-Dependent Signaling

Mycobacterium tuberculosis PPE51 Inhibits Autophagy by Suppressing Toll-Like Receptor 2-Dependent Signaling

ABSTRACT Autophagy is an ubiquitous homeostatic pathway in mammalian cells and plays a significant role in host immunity. Substantial evidence indicates that the ability of Mycobacterium tuberculosis (Mtb) to successfully evade immune responses is partially due to inhibition of autophagic pathways....

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Bibliographic Details
Main Authors: Emily J. Strong, Jia Wang, Tony W. Ng, Steven A. Porcelli, Sunhee Lee
Format: Article
Language:English
Published: American Society for Microbiology 2022-06-01
Series:mBio
Subjects:
Mycobacterium tuberculosis
autophagy
host-microbe interaction
innate immunity
mitogen-activated protein kinase ERK1/2
Toll-like receptor 2
Online Access:https://journals.asm.org/doi/10.1128/mbio.02974-21

Internet

https://journals.asm.org/doi/10.1128/mbio.02974-21

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