Silibinin Inhibits TGF-β-induced MMP-2 and MMP-9 Through Smad Signaling Pathway in Colorectal Cancer HT-29 Cells

Silibinin Inhibits TGF-β-induced MMP-2 and MMP-9 Through Smad Signaling Pathway in Colorectal Cancer HT-29 Cells

Background: Metastasis of cancer cells is the primary responsible for death in patients with colorectal cancer (CRC). Transforming growth factor-β (TGF-β)-induced matrix metalloproteinases (MMPs) are essential for the metastasis process. Silibinin is a natural compound extracted from the Silybum mar...

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Bibliographic Details
Main Authors: Zahra Zare, Tina Nayerpour Dizaj, Armaghan Lohrasbi, Zakieh Sadat Sheikhalishahi, Amirhooman Asadi, Mana Zakeri, Fahimeh Hosseinabadi, Omid Abazari, Mojtaba Abbasi, Parisa Khanicheragh
Format: Article
Language:English
Published: Tehran University of Medical Sciences 2021-01-01
Series:Basic & Clinical Cancer Research
Subjects:
Silibinin
Colorectal Neoplasms
TGF-β
MMP-2
MMP-9
Online Access:https://bccr.tums.ac.ir/index.php/bccrj/article/view/347

Internet

https://bccr.tums.ac.ir/index.php/bccrj/article/view/347

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