Roles of Bcl-2 and caspase-9 and -3 in CD30-induced human eosinophil apoptosis

Roles of Bcl-2 and caspase-9 and -3 in CD30-induced human eosinophil apoptosis

Background/purpose: Activation of cell surface CD30 by immobilized anti-CD30 monoclonal antibodies (mAb) induces strong apoptosis in human eosinophils. This anti-CD30 mAb-induced eosinophil apoptosis is inhibited by the addition of inhibitors of p38, ERK1/2 mitogen-activated protein kinases, and pho...

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Main Authors: Hye Jin Lee, Eun-Kyoung Lee, Young Eun Seo, Youn Ho Shin, Hwan Soo Kim, Yoon Hong Chun, Jong-Seo Yoon, Hyun Hee Kim, Man Yong Han, Chang-Keun Kim, Kyu-Earn Kim, Young Yull Koh, Jin Tack Kim
Format: Article
Language:English
Published: Elsevier 2017-04-01
Series:Journal of Microbiology, Immunology and Infection
Subjects:
apoptosis
Bcl-2
caspases
eosinophils
Online Access:http://www.sciencedirect.com/science/article/pii/S1684118215007732

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http://www.sciencedirect.com/science/article/pii/S1684118215007732

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