DGH-GO: dissecting the genetic heterogeneity of complex diseases using gene ontology

DGH-GO: dissecting the genetic heterogeneity of complex diseases using gene ontology

Abstract Background Complex diseases such as neurodevelopmental disorders (NDDs) exhibit multiple etiologies. The multi-etiological nature of complex-diseases emerges from distinct but functionally similar group of genes. Different diseases sharing genes of such groups show related clinical outcomes...

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Bibliographic Details
Main Authors: Muhammad Asif, Hugo F. M. C. Martiniano, Andre Lamurias, Samina Kausar, Francisco M. Couto
Format: Article
Language:English
Published: BMC 2023-04-01
Series:BMC Bioinformatics
Subjects:
Unsupervised learning
Dimension reduction
Gene ontology
Functionally similarities
Semantic similarity
Genetic heterogeneity
Online Access:https://doi.org/10.1186/s12859-023-05290-4

Internet

https://doi.org/10.1186/s12859-023-05290-4

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