Intestinal Farnesoid X Receptor Activation by Pharmacologic Inhibition of the Organic Solute Transporter α-β

Intestinal Farnesoid X Receptor Activation by Pharmacologic Inhibition of the Organic Solute Transporter α-β

The organic solute transporter α-β (OSTα-OSTβ) mainly facilitates transport of bile acids across the basolateral membrane of ileal enterocytes. Therefore, inhibition of OSTα-OSTβ might have similar beneficial metabolic effects as intestine-specific agonists of the major nuclear receptor for bile aci...

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Bibliographic Details
Main Authors: Sandra M.W. van de Wiel, D. Rudi de Waart, Ronald P.J. Oude Elferink, Stan F.J. van de Graaf
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Subjects:
Fluorescence Resonance Energy Transfer (FRET)
FXR
OSTα-OSTβ
Bile Acids
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X17301662

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http://www.sciencedirect.com/science/article/pii/S2352345X17301662

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