Amyloid β-based therapy for Alzheimer’s disease: challenges, successes and future

Abstract Amyloid β protein (Aβ) is the main component of neuritic plaques in Alzheimer’s disease (AD), and its accumulation has been considered as the molecular driver of Alzheimer’s pathogenesis and progression. Aβ has been the prime target for the development of AD therapy. However, the repeated f...

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Bibliographic Details
Main Authors: Yun Zhang, Huaqiu Chen, Ran Li, Keenan Sterling, Weihong Song
Format: Article
Language:English
Published: Nature Publishing Group 2023-06-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-023-01484-7