Partitioning and Spatial Distribution of Drugs in Ocular Surface Tissues

Partitioning and Spatial Distribution of Drugs in Ocular Surface Tissues

Ocular drug absorption after eye drop instillation has been widely studied, but partitioning phenomena and spatial drug distribution are poorly understood. We investigated partitioning of seven beta-blocking drugs in corneal epithelium, corneal stroma, including endothelium and conjunctiva, using is...

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Bibliographic Details
Main Authors: Anusha Balla, Seppo Auriola, Angus C. Grey, Nicholas J. Demarais, Annika Valtari, Emma M. Heikkinen, Elisa Toropainen, Arto Urtti, Kati-Sisko Vellonen, Marika Ruponen
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Pharmaceutics
Subjects:
cornea
conjunctiva
drug absorption
permeation
beta-blocking agent
MALDI-IMS
Online Access:https://www.mdpi.com/1999-4923/13/5/658

Internet

https://www.mdpi.com/1999-4923/13/5/658

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