FMRP phosphorylation and interactions with Cdh1 regulate association with dendritic RNA granules and MEF2-triggered synapse elimination

FMRP phosphorylation and interactions with Cdh1 regulate association with dendritic RNA granules and MEF2-triggered synapse elimination

Fragile X Messenger Ribonucleoprotein (FMRP) is necessary for experience-dependent, developmental synapse elimination and the loss of this process may underlie the excess dendritic spines and hyperconnectivity of cortical neurons in Fragile X Syndrome, a common inherited form of intellectual disabil...

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Bibliographic Details
Main Authors: Julia R. Wilkerson, Marius F. Ifrim, Arielle N. Valdez-Sinon, Patricia Hahn, Jacob E. Bowles, Gemma Molinaro, Aleksandra Janusz-Kaminska, Gary J. Bassell, Kimberly M. Huber
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Neurobiology of Disease
Subjects:
FMRP
Synapse elimination
MEF2
Cdh1
Hippocampal CA1
Online Access:http://www.sciencedirect.com/science/article/pii/S096999612300150X

Internet

http://www.sciencedirect.com/science/article/pii/S096999612300150X

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