DNA-damaged podocyte-CD8 T cell crosstalk exacerbates kidney injury by altering DNA methylation

DNA-damaged podocyte-CD8 T cell crosstalk exacerbates kidney injury by altering DNA methylation

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Summary: Recent epigenome-wide studies suggest an association between blood DNA methylation and kidney function. However, the pathological importance remains unclear. Here, we show that the homing endonuclease I-PpoI-induced DNA double-strand breaks in kidney glomerular podocytes cause proteinuria,...

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Bibliographic Details
Main Authors: Ran Nakamichi, Akihito Hishikawa, Shunsuke Chikuma, Akihito Yoshimura, Takashi Sasaki, Akinori Hashiguchi, Takaya Abe, Tomoko Tokuhara, Norifumi Yoshimoto, Erina Sugita Nishimura, Eriko Yoshida Hama, Tatsuhiko Azegami, Takashin Nakayama, Kaori Hayashi, Hiroshi Itoh
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:Cell Reports
Subjects:
CP: Immunology
CP: Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723003133

Internet

http://www.sciencedirect.com/science/article/pii/S2211124723003133

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